Synthesis of Guanidinopyrimidine Derivatives and Their Biological Activities

Present paper deals with the synthesis of guanidinopyrimidine derivatives from substituted-biguanides, and with thier biological activities. 2-Arylguanidino-4,6-dimethylpyrimidine derivatives had stronger herbicidal activity than 2-alkylguanidines. Espec ia l ly , 2-phenethylguanidino-4,6_dimethylpyrimidine inhib i ted a lmost the growth of radish roots at the concentration of 50 ppm, while at the concentration of 10 ppm it stimulated the growth of radish roots remarkably. For the molting of housefly there were no strikingly effective compounds. However, 4,6-dimethylpyrimidine derivatives made the pupation delay, e x c e p t 2-morpholinoguanidino-4,6_dimethylpyrimidine. O n the other hand, 4-hydroxy-6-methyl-derivatives seemed to accelerate it.